Winthrop is an unincorporated community in southwest Buchanan County, in the U.S. state of Missouri. The community is just east of the Missouri River and Atchison, Kansas on US Route 59 and Missouri routes 45 and 273. Rushville is approximately 4.5 miles northeast on US Route 59 and Lewis and Clark Village adjacent to the Louis and Clark State Park and lake is 3.5 miles southeast.
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