LOCATION United States

Matlacha Isles-Matlacha Shores, Florida

Matlacha Isles-Matlacha Shores is an unincorporated community and census-designated place (CDP) in Lee County, Florida, United States. The population was 227 at the 2020 census, down from 229 at the 2010 census. It is part of the Cape Coral-Fort Myers, Florida Metropolitan Statistical Area.

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